The Functional Genomics Center Zurich (FGCZ) is a joint state-of-the-art research facility of the ETH Zurich and the University of Zurich. Collaborating with the Zurich Life Science research community, the FGCZ engages in research and technology development projects in genomics, transcriptomics, proteomics, metabolomics, and bioinformatics.
Activities of the FGCZ range from research and development collaborations with academic and industry partners to standard service-for-fee analyses.
Analysis of genomes, gene expression, and regulation is performed using latest microarray technologies and next generation sequencing. Identification of proteins and proteomes, as well as metabolites in large numbers and from complex biological specimens is performed using cutting edge mass spectrometry technologies. Providing expertise not only for analytical data but also for upstream (sample preparation) and downstream (data analysis and interpretation) workflow components ensures most efficient use of the technologies and invested resources. In addition, several analytical technologies can be customized to the projects needs, including custom-fabricated microarrays of nucleic acids, proteins, peptides, and small molecules.
The FGCZ analytical experience is based on an average of more than 150 new initiated research projects every year. As of the end of 2010, a total of more than 900 projects involving close to 2000 scientists from 340 research institutes and independent groups of ETH Zurich and the University of Zurich plus external academic and industrial partners have been supported by the FGCZ.
Genomics / Transcriptomics
- Next generation sequencing (Applied Biosystems SOLiD 4 (2), Roche GS FLX)
- High density microarraying (Affymetrix GeneChip, Agilent, Nimblegen)
- Custom microarraying (non-contact and contact spotted)
- Multi-wavelength confocal laser scanning and spectral reading
Proteomics / Metabolomics
- Identification, sequencing, quantification, and structure analysis of proteins and metabolites from samples of varying complexity using mass spectrometry (Thermo Hybrid Orbitrap (4, 2 incl. ETD), Ion Trap FT-ICR, Linear Ion Trap, Triple Quadrupole (2); AB Sciex and Bruker MALDI-TOF/TOF (2) and MALDI-TOF; AB Sciex TripleTOF and QTRAP, Waters Synapt G2 Q-TOF (2), Waters GC-TOF).
Prof. Dr. Ralph Schlapbach, Managing Director
ETH Zurich / University of Zurich, Functional Genomics Center Zurich, Winterthurerstrasse 190
Phone: +41 (0)44 635 39 21 /22